Lasagna has always held a special place at our family table. I remember helping my dad layer the noodles, meat, and cheese every Sunday, eagerly awaiting that first cheesy, savory bite. But as I began focusing more on my fitness journey, I found myself seeking ways to enjoy the foods I love without compromising my nutrition goals.
That’s when the idea for high-protein lasagna came to life — a hearty, muscle-building version of the beloved classic, packed with lean meat, low-fat cheese, protein-rich pasta, and smart ingredient swaps. This lasagna doesn’t just satisfy comfort food cravings — it fuels your body while keeping flavors bold and textures satisfying.
Whether you’re an athlete looking to hit your macros or a busy parent trying to sneak in more nutrition, this recipe is your go-to solution. It’s also a fantastic meal prep option, reheats beautifully, and leaves you feeling full and energized.
Why People Love High Protein Lasagna Recipe?
This protein-packed lasagna strikes the perfect balance between health and indulgence. It’s comforting yet clean, hearty but guilt-free. Unlike traditional versions loaded with fat and empty carbs, this version supports muscle recovery, promotes satiety, and keeps blood sugar stable.
People love it for:
- The same savory, cheesy flavors they expect from classic lasagna
- The high protein content that supports muscle repair and growth
- Customizability with plant-based or gluten-free options
- Its ability to satisfy the whole family, fitness buffs and picky eaters alike
Ingredients Needed for High Protein Lasagna Recipe
Protein-Packed Meat Sauce:
- 1 lb (450g) lean ground turkey or ground chicken (93% lean or higher)
- 1 tablespoon olive oil
- 1 medium onion, diced
- 3 garlic cloves, minced
- 1 ½ cups marinara sauce (look for low-sugar, high-fiber)
- 1 tablespoon tomato paste
- 1 teaspoon Italian seasoning
- Salt and black pepper, to taste
Cheese Layer:
- 1 ½ cups low-fat cottage cheese or part-skim ricotta
- 1 cup plain nonfat Greek yogurt (adds extra protein!)
- 1 large egg
- ¼ cup grated Parmesan cheese
- ½ teaspoon garlic powder
- ½ teaspoon dried basil
Noodles & Assembly:
- 9–12 high-protein lasagna noodles (like chickpea or lentil pasta)
- 1 ½ cups reduced-fat mozzarella cheese, shredded
- Fresh parsley, for garnish
Ingredient Variations & Substitutions
- Meat Alternatives: Use lean ground beef, bison, or even plant-based meat crumbles for a vegetarian option.
- Cheese Swap: Replace cottage cheese with ricotta or use vegan cheese for dairy-free.
- Extra Veggies: Add chopped spinach, zucchini, mushrooms, or bell peppers to the meat sauce.
- Pasta Alternatives: For lower carbs, try zucchini slices or eggplant as noodle replacements.
- Vegan Option: Use tofu-based ricotta, plant-based protein crumbles, and dairy-free cheese.
How to Make High Protein Lasagna?
Step 1: Prepare Protein-Rich Meat Sauce
In a skillet, heat olive oil over medium heat. Sauté onions for 3–4 minutes until translucent. Add garlic and cook another minute. Add ground turkey, breaking it up as it browns. Once cooked through, stir in tomato paste, marinara, and Italian seasoning. Simmer for 10–15 minutes until thick and fragrant.
Step 2: Make the Cheese Mixture
In a bowl, combine cottage cheese (or ricotta), Greek yogurt, egg, Parmesan, garlic powder, and basil. Mix until creamy and smooth.
Step 3: Cook High-Protein Noodles
Boil noodles according to package instructions until al dente. Drain and set aside on parchment paper to prevent sticking.
Step 4: Assemble the Lasagna
In a 9×13-inch baking dish, spread a thin layer of meat sauce. Lay down 3–4 noodles. Spread one-third of the cheese mixture over the noodles, then add a layer of meat sauce and a sprinkle of mozzarella. Repeat layers, ending with sauce and a final layer of mozzarella on top.
Step 5: Bake to Perfection
Cover with foil and bake at 375°F (190°C) for 30 minutes. Remove foil and bake an additional 10 minutes until the cheese is golden and bubbling.
Step 6: Rest and Serve
Let the lasagna rest for 10–15 minutes before slicing. Garnish with fresh parsley and serve hot.

Pro Tips for a Perfect High Protein Lasagna
- Use a deep dish to avoid overflow while layering.
- Drain excess moisture from vegetables if using (e.g., spinach or mushrooms).
- Use full-fat cheese sparingly for added richness without overloading calories.
- Let it sit before slicing — this helps everything set and makes cleaner portions.
- Make it ahead and store in the fridge; the flavors intensify overnight.
Final Thoughts on High Protein Lasagna Recipe
This high-protein lasagna recipe is a beautiful example of how nourishing meals can also be deeply satisfying. With its rich layers of lean meat, gooey cheese, and high-protein pasta, it offers all the comfort of the traditional dish — but with a fitness-friendly twist. Whether you’re meal prepping, bulking, or just aiming for a balanced diet, this lasagna is an absolute winner. Make it once, and it might just become a staple in your kitchen rotation.
Muscle-Building High Protein Lasagna Recipe
This high-protein lasagna is a nutritious twist on a timeless comfort food favorite. Made with lean ground turkey, protein-rich cottage cheese, Greek yogurt, and high-protein noodles, each serving delivers over 35g of protein without sacrificing flavor. Layered with savory marinara, creamy low-fat cheese, and aromatic Italian herbs, it's perfect for athletes, meal preppers, or anyone looking to enjoy a hearty, muscle-fueling meal.

Ingredients
Protein-Packed Meat Sauce:
Cheese Layer:
Noodles & Assembly:
Instructions
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In a skillet, heat olive oil over medium heat. Sauté onions for 3–4 minutes until translucent. Add garlic and cook another minute. Add ground turkey, breaking it up as it browns. Once cooked through, stir in tomato paste, marinara, and Italian seasoning. Simmer for 10–15 minutes until thick and fragrant.
-
In a bowl, combine cottage cheese (or ricotta), Greek yogurt, egg, Parmesan, garlic powder, and basil. Mix until creamy and smooth.
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Boil noodles according to package instructions until al dente. Drain and set aside on parchment paper to prevent sticking.
-
In a 9x13-inch baking dish, spread a thin layer of meat sauce. Lay down 3–4 noodles. Spread one-third of the cheese mixture over the noodles, then add a layer of meat sauce and a sprinkle of mozzarella. Repeat layers, ending with sauce and a final layer of mozzarella on top.
-
Cover with foil and bake at 375°F (190°C) for 30 minutes. Remove foil and bake an additional 10 minutes until the cheese is golden and bubbling.
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Let the lasagna rest for 10–15 minutes before slicing. Garnish with fresh parsley and serve hot.
Nutrition Facts
Servings 4
- Amount Per Serving
- Calories 385kcal
- % Daily Value *
- Total Fat 16g25%
- Saturated Fat 5g25%
- Cholesterol 85mg29%
- Sodium 580mg25%
- Total Carbohydrate 26g9%
- Dietary Fiber 4g16%
- Sugars 5g
- Protein 37g74%
- Calcium 210 mg
* Percent Daily Values are based on a 2,000 calorie diet. Your daily value may be higher or lower depending on your calorie needs.